Ravi Teja Bodepudi
Postanesthetic Complications in 68 Pediatric Patients with Mitochondrial Cytopathy — A Retrospective Review

SchoolBrecksville-Broadview Heights High School


ProgramScience


MentorMarco Maurtua, MD


DepartmentGeneral Anesthesia


Research
Postanesthetic Complications in 68 Pediatric Patients with Mitochondrial Cytopathy — A Retrospective Review
Hypothesis
The purpose of our study was to determine the most common postanesthetic complications suffered by patients with Mitochondrial Cytopathy (MC), and to determine the possible relationship to specific anesthetic medications. The hypothesis is anesthetic drugs would have a negative impact on patients with mitochondrial cytopathy.
Methodology
Patients with metabolic disorders were identified through the Cleveland Clinic computerized patient records database. From the initial patient records searched, 68 pediatric patients had confirmed MC diagnosis by clinical findings in addition to laboratory tests and muscle biopsies. The selected patient records were retrospectively reviewed focusing on the anesthetic management to review anesthetic complications.
Outcomes
The most common post operative complications were neurological and the least common were respiratory. The most common surgery performed was a muscle biopsy. The average age of the patients was 13 years. Most patients with mitochondrial cytopathy experienced problems in a single complex. The most affected complexes among patients were 1 (20 patients) and 3 (17 patients). Unspecified complexes affected a total of 27 patients. No patients experienced immediate adverse post operative complications. It is difficult to link specific anesthetic drugs administered to certain complications because some complications existed preoperatively and in other cases multiple drugs or anesthetic agents were used.

Interpretations