Emerson Thacker Neuropathic Pain Study After Spinal Cord Injury (SCI)
SchoolCuyahoga Heights High School
MentorChing-Yi Lin, PhD
Neuropathic Pain Study After Spinal Cord Injury (SCI)
We hypothesize that a dorsal column crush will induce the development of neuropathic pain by assessment of pain-associated mechanical allodynia and thermal hyperalgesia.
After SCI, two behavioral tests are performed. 1) Mechanical Allodynia —sensitivity to non-noxious mechanical stimuli will be tested by assessing the “hind paw withdrawal reflex.” Filaments with sequentially increasing or decreasing force will be used to determine the withdrawal threshold. 2) Thermal Hyperalgesia — withdrawal latency will be tested with a thermal nociceptive stimulus. A movable infrared generator with a timer is positioned directly beneath the plantar surface of the hind paw of a rat.
When exposed to a non-noxious mechanical stimuli, mechanical allodynia starts to develop six weeks post dorsal column crush and will gradually get worse. When exposed to thermal nociceptive stimulus, no thermal hyperalgesia developed over the 6-week observation period after SCI.